Effect of anti-CD59 on CVF-induced platelet activation
- VernacularTitle:抗CD59对CVF激活人血小板的影响
- Author:
Xinxue LIAO
;
Lichun WANG
;
Hong MA
;
Shoujian HUANG
;
Weiyi MAI
;
Chon FENG
- Publication Type:Journal Article
- Keywords:
Complement;
Blood platelets;
Anti-CD59
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the reactions of human platelet to active complement and the effects of anti-CD59 on human platelet activation induced by complement. METHODS: By applying CVF to activate complement, the platelet aggregation and release reactions induced by activated complement with or without appling anti-CD59 with different doses to block the complement modulative protein CD59 in healthy individuals, were observed. RESULTS: CVF induced platelet release and significant and lasting metamorphosis in healthy individuals, but platelet aggregation was not observed. CVF-induced platelet metamorphosis showed positive linear correlation to lg concentration of CVF (r=0 970. P
