The oxidative modification of high density lipoprotein and atherosclerosis
- VernacularTitle:高密度脂蛋白氧化修饰与动脉硬化
- Author:
Chunni ZHANG
;
Jianmei WAN
- Publication Type:Journal Article
- Keywords:
Lipoproteins,HDL;
Oxidants;
Inflammation;
Atherosclerosis
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The reduced level of high density lipoprotein (HDL) in plasma is a strong predictor of atherosclerotic vascular disease risk. However, like low density lipoprotein (LDL), HDL is readily oxidized by a variety of oxidants in vitro . This review briefly discussed about the susceptibility of HDL to oxidation, the site and physiologic oxidants of HDL oxidation in vivo ,structural change in oxidized HDL, as well as the influence of different changes in structure of oxidized HDL on the protective function of HDL against atherosclerosis.
