Determination of Ciprofloxacin(CIPRO)and Metronidazole(MNZ)in Compound Ciprofloxacin Ear Drops by the Method of Nodical Polyploid UV-Spectrophotometry
- VernacularTitle:交点倍数法测定复方环丙沙星滴耳液中两组分的含量
- Author:
Hongwei LI
;
Qin LUO
;
Xiangan YU
- Publication Type:Journal Article
- Keywords:
nodical polyploid;
UV-spectrophotometry;
ciprofloxacin;
metronidazol
- From:
China Pharmacy
1991;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To simultaneously determine the contents of CIPRO and MNZ in compound ciprofloxacin ear dro_ ps by nodical polyploid UV-spectrophotometry.METHODS:CIPRO and MNZ were nodical absorption at wavelength of350.0nm and this was just the sum of isoabsorptive point of two components while DXM did not absorb UV ray at this point.Therefore350.0nm was adopted as the detecting wavelength for these two components.RESULTS:The average recovery and relative standard deviation of CIPRO were99.7%and1.4%respectively.The average recovery and relative standard de?viation of MNZ were100.7%and1.6%respectively.CONCLUSION:The method is accurate,rapid,simple and sensitive.This method can be used to control the quality of this preparation.
