The Therapeutic Effect of Ginkgo Biloba Extract on Hypoxic Ischemic Hepatic Damage of Neonatal Rats
- VernacularTitle:银杏提取物对新生大鼠缺氧缺血性肝损伤的治疗作用
- Author:
Suoying WANG
;
Shaoming SONG
;
Jiannong WU
- Publication Type:Journal Article
- Keywords:
Ginkgo biloba;
Plant extracts;
Anoxia;
Ischemia;
Liver diseases
- From:
Chinese Journal of Perinatal Medicine
1998;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the therapeutic effect of extract of ginkgo biloba (EGB) on hepatic damage of neonatal rats with hypoxic ischemic brain damage(HIBD). Methods Sixty six Sprague Dawley(SD) neonatal rats were divided into four groups: groupⅠincluded neonatal rats with hypoxic ischemic hepatic damage after HIBD group I, ( n=30 ), groupⅡ( n=24 ) was those with EGB-treated, groupⅢ ( n=6 ) was those with saline-treated and groupⅣ ( n=6 ) which had sham operation. ICAM-1 of liver was detected at different times in the first two groups after HIBD and the rest groups by immunohistochemical ABC method. Simultaneously HE was employed to display neutrophil infiltrations in hepatic tissue and pathologic characteristics of liver cells. Results The expression of ICAM-1 increased at 24 h [(52.5?17.0)%] with resupply oxygen, peaked at 48 h [ (76.5 ?11.9)%] ( H=23.9,P
