Expression of uridine diphosphate glucuronosyl transferase 1 A1 mRNA in mice with chronic liver injury
- VernacularTitle:小鼠UGT1 A1 mRNA在慢性肝损伤时的表达
- Author:
Junquan MO
;
Qingjia OU
;
Jingsong HE
- Publication Type:Journal Article
- Keywords:
LIVER DISEASES/metab;
URIDINE DIPHOSPHATE GLUCURONOSYL TRANSFERASE 1 A1/metab;
GENE EXPRSSION;
DISEASE MODELS,ANIMAL
- From:
Chinese Journal of General Surgery
1997;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of chronic liver injury on the expression of uridine diphosphate glucuronosyltransferase(UGT) 1A1 mRNA in mice. Methods Chronic liver injury model was induced by feeding CCl 4 in mice.Thirty mice were randomly divided into three groups:control group,experimental group 1(CCl 4 was given for 1 month),and experimental group 2(CCl 4 was given for 2 months).The liver function was tested;and the expression of UGT1A1 mRNA in the 3groups was analysed by RT-PCR. Results There was significant difference in the expression of UGT1A1 mRNA between the 3 groups(P
