Study on Chemokines and Their Receptors in the Patients with Condyloma Acuminatum
- VernacularTitle:尖锐湿疣患者趋化性细胞因子及其受体的研究
- Author:
Qifeng QIAN
;
Mingxia ZHANG
- Publication Type:Journal Article
- Keywords:
Condylomata acuminata;
Chemokines;
Receptors,chemokine
- From:
Chinese Journal of Dermatology
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the role of serum chemokines and their receptors in the pathogenesis of condyloma acuminatum(CA).Methods Serum levels of interleukin8(IL-8),interferon?-inducible pro-tein10(IP-10),monocyte chemotactic protein1(MCP-1),macrophage inflammatory protein1?(MIP-1?),reg-ulated upon activation,normal T cell expressed and secreted factor(RANTES)and macrophage-derived chemokine(MDC)were determined by enzyme-linked immunosorbent assay(ELISA)in30patients with CA and30normal controls.Meanwhile,chemokine receptors,CXCR1,CXCR3,CCR2and CCR5on peripheral blood CD3 + T-lymphocytes from20patients with CA were analyzed by flow cytometry with two-color im-munofluorescent staining.Results Serum levels of IP-10and MIP-1?were significantly higher in CA patients than those in controls(P
