Antimicrobial Susceptibility of Mycoplasma and Clinical Response to Antimicrobial Agents(Spectinomycin etc.)in Genitourinary Mycoplasma Infection
- VernacularTitle:大观霉素等对泌尿生殖道支原体的药敏试验及其临床疗效的观察
- Author:
Deli CHEN
;
Yuankang YE
;
Zhaohui CAI
;
Xingwu CAO
;
Huilin QIU
;
Chonggao XIE
;
Liangliang SHEN
;
Jie CHEN
;
Zhenyu LU
;
Shaohua TU
;
Shaofen LONG
;
Youai CAO
;
Hewu JIN
;
Wenzhi BAI
;
Mei JIANG
;
Zhenjun GUO
;
Suhong YAO
- Publication Type:Journal Article
- Keywords:
Spectinomycin;
Mycoplasma hominis;
Ureaplasma urealyticum;
Microbial sensitivity tests
- From:
Chinese Journal of Dermatology
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the antimicrobial susceptibility of spectinomycin?minocycline?azithromycin and sparfloxacin to mycoplasma(Uu and Mh)and therapeutic effect of spectinomycin to my-coplasma infection in genitourinary tract.Methods①The susceptibility test:each of the4drugs was divided into two concentrations.One was at1?g/mL(sensitive concentration)and the other was at4?g/mL(resistant concentration).If mycoplasma does not grow in both concentrations,it means the drug tested is sensitive.If it grows in both concentrations,the drug tested is resistant.If mycoplasma grows in lower concentration and does not in higher concentration,it means moderate sensitive.②Treatment regimen:Spectinomycin was injected,2g/d IM,for7-10days as a course of treatmeant.Patients were followed-up7days later and2~4weeks after treatment.Results①Among1658specimens,519were found Uu positive,and61Mh positive.The resis-tance rates of Uu to4different drugs were:7.7%for minocycline,21.4%for sparfloxacin,13.9%for azithromycin and7.3%for spectinomycin.Whereas,those of Mh were:18.0%,45.9%,54.1%,and29.5%re-spectively.②The clinical effect of spectinomycin was:out of43treated patients,37(86.0%)cured,4(9.3%)markedly improved,2(4.7%)failed.Total effective rate was95.3%and so was the elimination rate of my-coplasma.Conclusion The resistant rate of mycoplasma to spectinomycin is lower than that to minocycline?azithromycin and sparfloxacin,and the former is widely used in the treatment of mycoplasma(especially Uu)infection,with a satisfactory clinical effect.
