Expression of MDM2 Protein and MDM 2mRNA in Condyloma Acuminatum
- VernacularTitle:MDM2蛋白和MDM2 mRNA在尖锐湿疣中的表达
- Author:
Yating TU
;
Li ZHU
;
Houjun LIU
- Publication Type:Journal Article
- Keywords:
Condylomata acuminata;
Oncogenes;
MDM2
- From:
Chinese Journal of Dermatology
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of MDM2in the cell proliferation and carcinogenesis in condyloma acuminatum(CA).Methods The technique of immunohistochemistry and in situ hybridization were used to detect the expression of MDM2protein and mRNA in skin lesions of CA and normal skin of genital area.Polymerase-chain reaction(PCR)was used to type HPV DNA.Results Out of32CA specimens,the expression of MDM2protein was found in18(56.25%),the expression of MDM2mRNA was found in22(68.75%),while co-expression of MDM2protein and MDM2mRNA was found in14.According to PCR results,HPV6/11subtype was shown in28out of32CA specimens(87.5%),and HPV16/18subtype was shown in4out of32(12.5%).In eighteen out of positive specimens expressing MDM2protein,HPV6/11subtype was shown in15and HPV16/18subtype3.In twenty-two positive specimens expressing MDM2mRNA,there were HPV6/11subtype in18,and4were HPV16/18subtype.No expression of MDM2protein and MDM2mRNA was observed in normal skin.Conclusion The overexpression of MDM2may be involved in malignant proliferation and carcinomatous change of condyloma acuminatum.
