The Effect of Chinese Herbal Capsule on Experimental Genital Herpes
- VernacularTitle:荧光定量PCR观察中药抗病毒胶囊对豚鼠HSV-2系统感染的影响
- Author:
Ruiqiang FAN
;
Xinsheng CHEN
;
Guowei XUAN
;
Hongyi LI
;
Fenghao CHI
- Publication Type:Journal Article
- Keywords:
Anti-viral agents(TCD);
Herpes genitalis;
Guinea pigs;
Animals,laboratory
- From:
Chinese Journal of Dermatology
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mechanism of Chinese herbal capsule in the treatment of genital herpes.Methods Guinea pig model for genital herpes infection was established.HSV DNA from the cerebrum,spinal cord,cervical canal and vagina of guinea pigs was detected by fluorescent-quantitative PCR.Results The HSV DNA could be detected from all four kinds of tissues,with different copies of the virus in the different tissues,the highest in spinal cord,then in vagina,the least in cerebrum and cervical canal.There was statistical difference of HSV-DNA copies between herbal capsule group and control group(normal saline),whereas no statistical difference between herbal capsule group and aciclovir group.Conclusion The mechanism of the anti-virus herbal capsule in the treatment of experimental genital herpes might be related to blocking the latent infection and suppressing the replication of HSV.
