Detection of metabolism-associated genes expression in preeclamptic placenta by employing gene microarray
- VernacularTitle:应用基因芯片研究代谢相关基因在先兆子痫胎盘中的表达
- Author:
Zhanjun PANG
;
Fuqi XING
;
Jungui ZHOU
- Publication Type:Journal Article
- Keywords:
Gene microarray;
Pre-eclampsia;
Placenta;
Metabolism
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the change of some metabolism-associated genes expression in preeclamptic placenta. METHODS: The mRNA expression levels of metabolism-associated genes in preeclamptic or normal placenta were detected by employing complementary DNA microarray representing over 220 human hormone-associated genes. RESULTS: Many redox metabolism-related genes (GenBank: U78168, X16699, D32143, AL035079, AF069668, X53463, J03746, X02317, X91247, etc) were highly expressed in preeclamptic placenta compared with normal placenta. Additionally, the mRNA expression levels of some genes which were related to other metabolism such as hormone (GenBank: NM -001718, Z22535, M38180, M76665, X75252, J03258, U56725), were also highly expressed in preeclamptic placenta.CONCLUSION: The change of genes expression in placenta is associated with the change of metabolism in patients sufferring from preeclampsia.
