Effect of BCG on experimental asthma in a guinea pigmodel of allergen sensitization
- VernacularTitle:卡介苗对豚鼠实验性哮喘的预防性治疗作用
- Author:
Jinbao LIU
;
Nanshan ZHONG
;
Shunong LI
;
Zhongpei LIANG
;
Guifang WANG
;
Wei WU
- Publication Type:Journal Article
- Keywords:
BCG vaccine;
Asthma;
Guinea pigs
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To examine the effect of bacillus calmette-guerin (BCG) on experimental asthma in guinea pigs. METHODS: Guinea pigs were sensitized with BCG and then with ovalbumin (ip). Two weeks later, guinea pigs were challenged with ovalbumin (OVA) aerosol inhalation. Thirty one Guinea pigs were divided into three groups at random control group,OVA-treated group, BCG and OVA-treated group.RESULTS: Ovalbumin inhalation caused a marked airway infiltration of eosinophils and all the animals exhibit asthmatic symptoms. Pretreatment with BCG induced typical increase in lymphocytes and monocytes in peripheral blood and in bronchoalveolar lavage fluid (BALF). BCG markedly inhibited eosinophil infiltration and attenuated the asthmatic symptoms. CONCLUSION: These data suggest that BCG exerts an inhibitory effect on asthmatic inflammation.
