Effect of cornus officinalis glycosides ophthalmic solution on the corneal allograft rejection
- VernacularTitle:山茱萸总甙滴眼液防治角膜移植免疫排斥反应的实验研究
- Author:
Jing MENG
;
Jiansu CHEN
;
Chen LI
;
Songbin ZHAO
;
Haozhuang YANG
;
Suimei ZHANG
;
Jingfang DI
- Publication Type:Journal Article
- Keywords:
Fructurs corni;
Ophthalmic solutions;
Corneal transplantation;
Immunologic rejection
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the effect of cornus of ficinalis glycosides(COG) ophthalmic solution on the corneal allograft rejection by topical instillation. METHODS: The corneal transplantation model on the closed colony rats was established. The rejection time of all animals was recorded and compared by slit-lamp microscope. The pathologic changes were measured by immunohistochemistry and scanning electron microscope.RESULTS: The histopathological and immunohistochemistry findings showed that the lymphocytes, neovascularity and the expression of ICAM-1 in COG-treated group were significantly fewer than that in control group at 15 d after operation.CONCLUSION: COG ophthalmic solution prevents and suppresses the corneal allograft rejection.
