Dose-Response Relationship between Catalase and Superoxide dismutase Activity in Testes of Acutely Intoxicated Rats by Cadmium.
- Author:
Bo Young PARK
;
Jung Duck PARK
;
Kyou Chull CHUNG
- Publication Type:Original Article
- MeSH:
Animals;
Cadmium Chloride;
Cadmium*;
Catalase*;
Decapitation;
Humans;
Male;
Peritoneal Cavity;
Rats*;
Rats, Sprague-Dawley;
Superoxide Dismutase*;
Superoxides*;
Testis*
- From:Korean Journal of Preventive Medicine
1988;21(2):295-306
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Dose-response relationship among blood cadmium concentrations, catalase and superoxide dismutase activities were studied with acutely intoxicated rats by cadmium. The Sprague-Dawley male rats to which single dose of 1-32 mg/kg CdCl2 were administered into peritoneal cavity were sacrificed by decapitation at 3-36 hours after the administration. Cadmium concentrations in blood increased significantly with dose of CdCl2 administered and reached peak level at 3 hours later. Catalase activities in rats' tests were not correlated with exposure time elapsed after the administration in rats to which 1-2 mg/kg of CdCl2 were administered, but they showed linear relationship with time in groups to which 4-32 mg/kg of CdCl2 were administered. Cu, Zn-SOD activities in tests of acutely intoxicated rats by cadmium were not altered either by dosage or by time elapsed after the administration. Mn-SOD activities in the tests were also not influenced by dosage of 1-2 mg/kg CdCl2, but remarkably inactivated by dosage of 4-32 mg/kg CdCl2 with time elapsed after the administration. Neither catalase, Cu, Zn-SOD nor Mn-SOD activities of tests were correlated with blood cadmium concentrations in acutely intoxicated rats by cadmium.
