Effect of amiodarone and metoprolol on platelet activation, fibrinolytic activity and vasoactive mediators in acute myocardial infarction in rabbits
- VernacularTitle:胺碘酮、美托洛尔对家兔急性心肌梗死血小板活化、纤溶活性、内皮血管活性物质的影响
- Author:
Hengliang LIU
;
Yunkai KANG
;
Lihua WU
;
Yun KAI
;
Dongqin HAO
;
Jianwen CHAI
- Publication Type:Journal Article
- Keywords:
Platelet activation;
Nitric oxide;
Endothelins;
Amiodarone;
Metoprolol;
Myocardial infarction
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the significance of platelet activation, fibrinolytic activity and the changes of vasoactive mediators in acute myocardial infarction in rabbits and the intervention of amiodarone and metoprolol. METHODS: Fifty New Zealand white rabbits were randomly assigned to five groups, ten for each. Group Ⅰ: sham group, group Ⅱ: acute myocardial infarction(AMI) group, group Ⅲ: AMI and lidocaine group, group Ⅳ: AMI and amiodarone group, group Ⅴ: AMI and metoprolol group.The middle point of left ventricular coronary artery was ligated (groupⅡ,Ⅲ, Ⅳ and Ⅴ ) or a sham ligation(group Ⅰ). Four hours later, blood was collected for measuring plasma concentration of TXB 2, 6-Keto-PGF 1?, ET, NO, plasma activity of t-Pa and PAI.After that, the heart was taken out to evaluate the infarction size(IS). RESULTS: Plasma concentration of TXB 2, ET, NO and plasma activity of PAI were significantly higher in groupⅡ,Ⅲ, Ⅳ and Ⅴ than those in group Ⅰ(P0.05).Compared to group Ⅱ, plasma concentration of ET, NO and PAI activity were significantly decresed (P
