Acute pulmonary injury caused by echinococcus granulosus cyst fluid
- VernacularTitle:棘球蚴内容物导致肺损害的研究
- Author:
Bin XU
;
Meixiang LUAN
;
Shuyou PENG
;
Xinfeng ZHANG
;
Mulati DILI
;
Yingbin LUI
- Publication Type:Journal Article
- Keywords:
Echinococcosis, hepatic;
Pulmonary embolism;
Blood gas analysis;
Thromboxane B2;
Prostaglandins F
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: to establish an animals model of pulmonary embolism caused by echinococcus granulosus (E.g)cyst fluid. METHODS: Cyst fluid were isolated from sheep liver . Twenty-one rabbits were randomized into 3 groups: group Ⅰ(saline group), group Ⅱ(clear cyst fluid group), group Ⅲ (sand-contained cyst fluid group). Operation was performed on each animal to place a femoral artery catheter and a femoral vein catheter. Saline, clear cyst fluid or sand-contained cyst fluid were given to rabbits at a dose of 3 mL/kg body weigh . Observations were then made at 10, 30, 60 minutes to determine the changes of MAP, blood gas and vaso-active substance. Then ECT scanning image was obtained .After observation, all animals were killed and the lungs were harvested for histological examination by light microscopy. RESULTS: Remarkable decline of PaO 2 , MAP and rise of TXB 2, 6-keto-PGF 1? were observed in group Ⅲ and group Ⅱ(P
