Effects of profound hemodilution with 6% HES on coagulation and platelet function curve
- VernacularTitle:6%羟乙基淀粉深度血液稀释对家兔凝血曲线的影响
- Author:
Hui YANG
;
Peng WANG
;
Yuke TIAN
- Publication Type:Journal Article
- Keywords:
Hetastorch;
Hemodilution;
Blood coagulation
- From:
Chinese Journal of Anesthesiology
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of profound hemodilution with 6% HES (200/0.5) on coagulation.Methods Ten male new Zealand long-ear rabbits weighing (2.43 ?0.19) kg were anesthetized with intravenous thiopentone 8 mg-1 and tracheotomized and mechanically ventilated (VT = 15 ml-1 , RR = 24 bpm) . Anesthesia was maintained with intravenous infusion of thiopentone and succinylcholine. Femoral artery and vein were cannulated for BP and CVP monitoring. Hemodilution was performed in 6 steps at 30 min intervals. Blood was withdrawn from artery and simultaneously replaced by intravenous infusion of equal volume of 6% HES until Hct was 5 % -8 % . Blood samples were taken before hemodilution and 30 min after each step of hemodilution for determination of coagulation function curve using Sonoclot coagulation and platelet function analyzer. Results When Hct was 25%-30% there was no significant difference in coagulation function before and after hemodilution. When Hct was 15%-20% there was significant difference in ACT, TTP, clot rate and MCS before and after hemodilution but the normal coagulation process was not affected. When Hct
