The effect of mitomycin,5-fluorouracil and tamoxifen on human breast cancer cell lines
- VernacularTitle:丝裂霉素、5-氟尿嘧啶、三苯氧胺联合应用对人乳腺癌细胞株的作用
- Author:
Li TANG
;
Weixue TANG
;
Yi SHEN
;
Hong DUAN
;
Weiping ZHENG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Drug therapy, combination
- From:
Chinese Journal of General Surgery
1997;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the killing effects of MMC,5-Fu and TAM on human breast cancer cell lines (MCF-7 and MDA-MB-435S). MethodsThe MTT method and median-effect principle were used. ResultsKilling effects of drugs were enhanced as drug concentration increased while they were used alone or in combination. The median-effect concentration of TAM in conjunction with MMC was 1.65?10 -5 mmol/L,and that of TAM in conjunction with 5-Fu was 0.032 6 mmol/L. MMC was synergetic with 5-Fu at high concentration(CI1). The ratios of drug concentration and the sequence of administration were not related with the killing effects. ConclusionsA combination of MMC, 5-Fu and TAM has an increased killing effect on MCF-7 cell lines and questionable enhanced effect on MDA-MB-435S cell lines.
