A preliminary study on expression of caspase-3 in experimental brain contusion in rats
- VernacularTitle:实验性脑挫伤后caspase-3表达的免疫组织化学研究
- Author:
Xiping CHEN
;
Luyang TAO
;
Mei DING
- Publication Type:Journal Article
- Keywords:
Forensic pathology;
Cerebral contusion;
Casapse-3;
Immunohistochemistry;
Apoptosis
- From:
Chinese Journal of Forensic Medicine
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of caspase-3 in different post-traumatic intervals and severity of traumatic brain injury (TBI). Method Brain tissue samples of slight (n =24), moderate (n = 24) brain injury and control (n = 10) groups of rat were examined by immunohistochemical staining. Results Up-regulation of caspase-3 expression was found in tissues from traumatic brain injury as compared with controls in 1h after TBI, and lasted for 2 weeks. In tissues taken Ih, 12h, 24h, 72h, lweek and 2weeks after TBI there were different amount of positive celis in brain injuries of different severity. Con-clusion The expression of caspase-3 is different in brain injuries of different severity . These findings are valuable in appraising the severity of injuries.
