Study of the Mechanism of Cassia Obtusifolia L in Decreasing Blood-lipid
- VernacularTitle:决明子降血脂作用机制研究
- Author:
Juying HE
;
Songqing LIU
;
Yongfu PENG
- Publication Type:Journal Article
- Keywords:
Cassia obtusifolia;
hepatocyte culture;
liquid scintillation count;
decreasing blood-lipid action
- From:
China Pharmacy
1991;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the mechanism of Cassia obtusifolia L in decreasing blood-lipid.METHODS:Primary cultures of rat hepatocytes in vitro were used to determine the concentrations of proteins in hepatocytes by the method of Folin-phenol reagent and to assay the cholesterol synthesis from 14 C-acetate with liquid scintillation count.RESULTS:Ex?tract of Cassia obtusifolia L inhibited cholesterol synthesis from 14 C-acetate,but cassiaside B didn't affect cholesterol synthe?sis.CONCLUSION:The mechanism of extract of Cassia obtusifolia L in decreasing blood-lipid may result from inhibition of cholesterol synthesis,but inhibiting cholesterol synthesis may be not the main approach of cassiaside B in decreasing blood-lipid.
