Determination of Tinidazole in Yintai Cleaning Solution by HPLC
- VernacularTitle:高效液相色谱法测定阴泰洗液中替硝唑的含量
- Author:
Dan GUO
;
Yuan YAN
;
Pingbo MA
;
Zhiliang CHEN
- Publication Type:Journal Article
- Keywords:
tinidazole;
Yintai cleaning solution;
HPLC Fig1 HPLC chromatograms A.reference substance;
B.sample;
1.internal standard metronidazole(T R =5.744min);
2.tinidazole(T R =7.495min)
- From:
China Pharmacy
1991;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a HPLC method for determining the content of tinidazole in Yintal cleaning solu?tion.METHODS:Nova-Pak C 18 column was used.The mobile phase was methanol-water-glacial acetic acid(22∶78∶0.1). Internal standard was metronidazole.The UV detection wavelength was310nm.RESULTS:There was a good linerarity within the concentration range of20～100?g/ml of tinidazole in Yintai solution(r=0.9999).The average recovery was101.2%(n=5,RSD=1.16%).CONCLUSION:This method is simple,fast and accurate.
