Intestine mast cell and expression of oestrogen receptor in patients with irritable bowel syndrome
- VernacularTitle:肥大细胞及其雌激素受体在肠易激综合征发病机制中的作用
- Author:
Wei HAN
;
Jian CHEN
;
Jimman LI
- Publication Type:Journal Article
- Keywords:
Irritable bowel syndrome;
Mast cell;
Receptors, estrogen
- From:
Chinese Journal of Digestive Endoscopy
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of oestrogen receptors and enteric mast cells in the pathogenesis of irritable bowel syndrome (IBS) . Methods Biopsies from 59 patients with IBS and 24 control subjects were analyzed blindly for the number of mast cell ( MC ) , estrogen receptors and progestogen receptors in terminal ileum , caecum and descending colon (DC). Immunohistochemical methods were used to detect the estrogen receptors (ER) , progestogen receptors (PR) and MC. And double Immunohistochemical staining was used to manifest the expression of oestrogen receptors in intestinal MC. Results The cells positive for ER were morphologically similar to the MC (R = 0. 884, P
