Expression of Human Telomerase Reverse Transcriptase in Nasopharyngeal Carcinoma and its Clinical Significance
- VernacularTitle:鼻咽癌中端粒酶逆转录酶的表达及其临床意义的研究
- Author:
Jun HU
;
Baoan LIU
;
Senlin CHEN
- Publication Type:Journal Article
- Keywords:
HTERT;
Nasopharyngeal carcinoma;
Immunocytochemistry
- From:
Journal of Chinese Physician
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study was designed to investigate the expression of human telmerase reverse transcriptase (HTERT) in nasopharyngeal carcinoma (NPC) and its clinical significance.Methods Expression of HTERT in NPC and dysplasia of nasopharyngeal epithelium and chronic inflammation of nasopharyngeal epithelium were determined by immunocytochemical staining.The results were analysed,compared with the clinical TNM stage ,lymph node metastasis ,other places metastasis and prognostic survivals of the NPC patients.Results Positive rate of HTERT in NPC was 83 7%(70/84),while positive rate of HTERT in dysplasia of nasopharyngeal epithelium and chronic inflammation of nasopharyngeal epithelium both were 0 0%(0/8 and 0/16) (P0 05).The median survival of HTERT positive group was shorter than the nagative one.Conclusions Expression of HTERT may be a potential marker for clinical diagnosis of NPC and may has significance in predicting clinical TNM stage, metastasis and prognostic survival of the NPC patients.
