Effect of Artorvastatin on Tubulointerstitial Macrophage Proliferation in Unilateral Ureteral Obstructive Nephropathy
- VernacularTitle:阿托伐他汀对肾间质纤维化大鼠间质巨噬细胞增殖的影响
- Author:
Shaojiang TIAN
;
Ruhan JIA
;
Guohua DING
- Publication Type:Journal Article
- Keywords:
Interstitial fibrosis;
Macrophage;
M-CSF;
Atorvastatin
- From:
Journal of Chinese Physician
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of artorvastatin on macrophage accumulation in tubulointerstitium of unilateral ureteral obstructive (UUO) nephropathy and its possible mechanism.Methods Twenty-one rats were randomly divided into three groups: sham-operatipn, UUO, UUO+ artorvastatin. Immunohistochemistry staining of CD68 and M-CSF was used to define the macrophage accumulation and expression of interstitial M-CSF. Lipid profile in these groups was also determined. Results CD68 + cells and M-CSF expression were significantly increased at day 10 after UUO operation, this kind of CD68 + cell accumulation and M-CSF expression up-regulation were ameliorated by artorvastatin treatment. In UUO and atorvastatin treated groups, the number of macrophage was positively correlated with tubulointerstitial M-CSF expression. There was no significant difference about serum lipid among the three groups. Conclusion Atorvastatin can reduce interstitial macrophage accumulation in UUO nephropathy. This therapeutic effect might relate to down-regulation of tubulointerstitial M-CSF expression.
