Effects of Losartan on Neointimal Proliferation and Expression of Macrophages After Balloon Angioplasty of Atherosclerotic Aortic Arteries in Rabbits
- VernacularTitle:球囊成形术后氯沙坦对兔血管内膜增殖及巨噬细胞表达的影响
- Author:
Ying LIU
;
Jianjun LI
;
Gengshan LI
- Publication Type:Journal Article
- Keywords:
AT 1 antagonist;
Losartan;
Restenosis;
Angioplasty;
Macrophage;
Losartan
- From:
Journal of Chinese Physician
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Objective To investigate the effects of losartan on neointimal proliferation and macrophage count in neointima.Methods The rabbits underwent abdominal aorta balloon de-endothelialization,then received a 1 5 % cholesterol diet for 8 weeks.Abdominal aorta atherosclerosis model was performed in 16 rabbits.Immediately after operation, losartan was orally administered to the rabbits of the losartan group (10mg?kg -1 ?day -1 ), while the rabbits of the control group were given normal saline. Four weeks later the animals were killed and the excised artery segments were prepared for histomorphological observation and macrophages were investigated by immunohistochemistry analysis.Results Compared with the control group, the IT/MT ratio and IA/MA ratio of the losartan group were significantly reduced(P
