Mutation of P53 Gene in Ovarian Malignant Epithelial Tumors and Its Clinical Significance
- VernacularTitle:恶性卵巢上皮肿瘤的P53基因点突变及其意义
- Author:
Zhenguo WANG
;
Hong ZHU
;
Zhaoxia HE
- Publication Type:Journal Article
- Keywords:
Malignant epithelial tumor;
Ovarian;
P53gene;
Point mutation
- From:
Journal of Chinese Physician
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate whether P53 gene mutation was related with the pathogenesis of ovarian malignant epithelial tumors or not.Methods P53 gene mutation in exons 5-8 was detected by polymerase chain reaction product-single strand conformation polymorphism analysis (PCR-SSCP).Results The mutation in benign tumors: 3(10%) cases, but in malignant epithelial tumor:19(38%) cases(P0 05).Conclusions P53 gene mutation in exons 5-8 was probably related with the pathogenesis of ovarian malignant epithelial tumors, but was not related with histological grade.
