Expression of Interleukin-13 in Plasma and Renal Tisssue and Their Molecular Pathogenesis in Mesangial Proliferative Glomerulonephritis
- VernacularTitle:白细胞介素13在系膜增生性肾小球肾炎患者血浆及肾组织的表达
- Author:
Haiyan LIU
;
Xiaowen CHEN
;
Liming JIANG
- Publication Type:Journal Article
- Keywords:
MsPGN;
Non-IgA MsPGN;
IgAN;
Interleukin-13 (IL-13)
- From:
Journal of Chinese Physician
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The expression of IL-13 in plasma and renal tissue was studied to eluciate the molecular pathogenesis of Mesangial proliferative glomerulonephritis (MsPGN). Methods Plasma level of IL-13 in patients with MsPGN and in normal control groups were examined by ELISA. The expression of IL-13 in patients with MsPGN and in control group were examined by immune histochemistry ABC technique in renal tissue.Results Plasma levels of IL-13 in patients with MsPGN were significantly higher than that in control group,and the highest was found in IgAN;IL-13 expressions in glomerulus and tubulointerstitial zone in patients with MsPGN were higher than that in control group, and IL-13 expression in tubulointerstitial zone was more strong,but it was not distinctive difference between non-IgA MsPGN and IgAN. Conclusion IL-13 may play an important role in the molecular pathogenesis of MsPGN.
