T-lymphocyte Subset,TNF-?,IL-6,IL-8,sIL-2R Levels Have Relation To Hepatitis B Viral Replication
- VernacularTitle:T淋巴细胞亚群、TNF-?、IL-6、IL-8、sIL-2R与乙肝病毒复制的关系
- Author:
Yongnain SUN
;
Changxing HUANG
;
Zhuqing HUANG
- Publication Type:Journal Article
- Keywords:
T-lymphocyte subset;
Cytokines;
sIL-2R;
Hepatitis B virus;
Replication
- From:
Journal of Chinese Physician
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of T-cell subset,changes of TNF-?,IL-6,IL-8,sIL-2R levels in the sera and its role in development of chromic viral hepatitis B,in order to understand viral replication and clinical significance in patients with chronic hepatitis B(CVHB).Methods Alkaline phosphatase/antialkaline Phosphatase(APAAP) and ELISA techniques were used to detect the levels of T-cell subset in peripheral blood and serum TNF-?,IL-6,IL-8,sIL-2R in 290 patients with chronic hepatitis B.Results In the count of CD 4 + cell and CD 4 +/CD 8 + were significanyly lower,and in the count of CD 8 + cell and levels of TNF-?,IL-6,IL-8,sIL-2R in CVHB patients group were higher than in normal control group(P
