Clinical Investigation on Ganciclovir Applied to Treat Neonatal Congenital CMV Infection
- VernacularTitle:更昔洛韦治疗新生儿先天性巨细胞病毒感染的临床研究
- Author:
Pingyang CHEN
;
Zongde XIE
;
Tao WAN
- Publication Type:Journal Article
- Keywords:
Newborn;
Infent;
Congenital;
CMV infection;
Ganciclovir
- From:
Journal of Chinese Physician
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate therapeutic effects of ganciclovir on neonatal congenital CMV infection.Methods 40 cases of neonatal congenital CMV infection was divided into experimental group with ganciclovir(n=18) and control group with general treatment(n=22).The patients of experimental group were treated with higher dosage of ganciclovir:induced treatment 7 5mg/kg,intravenous drip every 12 hours,continous using for 14 days,then maintenance treatment,10mg/kg intravenous drip every day,for 3-day every week,maintenance treatment 2～3months.The patients of control group was treated with routine mehtod.Later on clinical situation,laboratory examination and virology result were compared in the two groups.Result There were significantly differences of clinical situation,laboratory examination and virology test result between posttreatment and pretreatment in experimental group(P0 05).Conclusions Using higher dosage,full course ganciclovir treating neonatal congenital CMV infection have remarkably efficacy in early the disease at the onset,so can be widespread in clinical practice.
