Expression of p53,PCNA and Bcl-2in Trichilemmal Carcinoma of Skin
- VernacularTitle:p53、增殖细胞核抗原和Bcl-2在皮肤外毛根鞘癌中的表达
- Author:
Xia GE
;
Qun XIE
;
Min YAO
- Publication Type:Journal Article
- Keywords:
Skin neoplasms;
Tricholemmal carcinoma;
Protein p53;
Proliferating cell nuclear antigen
- From:
Chinese Journal of Dermatology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinicopathologic features and the expression of p53,PCNA and Bcl-2in tricholemmal carcinoma.Methods Skin lesions were studied with HE staining and immunohis-tochemical markers for p53,PCNA and Bcl-2(S-P method)in22cases of skin tricholemmal carcinoma.Both morphological manifestations and immunohistochemical expression were observed.Results There were15fe-male and7male cases of tricholemmal carcinoma with the ages of40-79y,including16cases whose scalp were involved.Positive staining of p53,PCNA and Bcl-2was found in72%,100%and63%of patients,re-spectively.The positive cells of p53were diffusely distributed.PCNA-positive cells were increased along with the degree of differentiation.Significant differences of Bcl-2expression were found among the various degrees of differentiation(P
