Effects of Sini decoction on atherosclerosis and ceramide content of aorta in rabbits
- VernacularTitle:四逆汤对家兔动脉粥样硬化的形成及血管壁神经酰胺含量的影响
- Author:
Ziqing HEI
;
Weikang WU
;
Huilan SUN
;
Heqing HUANG
;
Hongmei TAN
;
Hanchua LUO
- Publication Type:Journal Article
- Keywords:
Atherosclerosis;
Ceramides;
Sini decoction
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the effects of Sini decoction on atherosclerosis(AS) and ceramide content of aorta in rabbits. METHODS: 28 rabbits were randomly divided into three groups. Control group was fed with a normal diet; High cholesterol group was fed 1% cholesterol and 5% fat diet; Sini decotion+ high cholesterol group was fed 1% cholesterol and 5% fat diet plus Sini decotion (4.2 g?kg -1 ?d -1 ). At the end of study, the plaque area were measured, the atorta ceramide and cell apoptosis were also detected. RESULTS: Sini decotion diminished lipid plaque area on the aortic endothelium, reduced the levels of aorta ceramide and the apoptosis index. CONCLUSION: Sini decoction has an inhibitory effect on AS, the mechanism may be that Sini decotion reduces concentration of ceramide in aorta.
