Activation and apoptosis of spleen lymphocytes in patients with viral myocarditis
- VernacularTitle:病毒性心肌炎脾脏淋巴细胞的活化与凋亡
- Author:
Jianding CHENG
;
Yuchuan CHEN
;
Hualan JING
;
Wei GUO
;
Shuiping LIU
- Publication Type:Journal Article
- Keywords:
Myocarditis;
Spleen;
Apoptosis;
Major histocompatibility complex II antigen
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the role of activation and apoptosis of splenic lymphocytes in the development of viral myocarditis (VMC). METHODS: Apotosis and MHC II antigen of splenic lymphocytes were detected in the VMC group (VMC, death, 8 cases) and control group (non-cardiac death, 4 cases) with TUNEL and immunohistochemistry methods.RESULTS: Compared with the control group, the increased expression of MHC II antigen and apoptosis were found in the splenic lymphocytes in the VMC group. CONCLUSION: These results suggest that the abnormality of the apoptosis/activation of splenic lymphocytes may be involved in the pathogenesis of VMC.
