Expression of endothelin system in pulmonary tissue in a canine pacing-induced congestive heart failure model
- VernacularTitle:快速起搏致充血性心力衰竭犬肺组织内皮素系统表达的变化
- Author:
Xiaochao CHEN
;
Wei WU
;
Chang FANG
;
Yingmei LIU
;
Niansang LUO
;
Xuming ZHANG
- Publication Type:Journal Article
- Keywords:
Heart failure, congestive;
Lung;
Dogs;
Endothelin-1
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To evaluate expression of the components of endothelin system in pulmonary tissue in a canine pacing-induced congestive heart failure model. METHODS: Twenty-one dogs were divided into 3 groups received 2 (pacing 2 group) or 4 weeks (pacing 4 group) rapid right ventricular pacing, respectively, whereas the other group consisted of 7 dogs received sham-operation as control group. Haemodynamic parameters were detected via left and right heart catheterization. Plasma endothelin-1 was determined by means of RIA. In addition, RT-PCR was used to quantify expression of mRNA of components of endothelin system using ?-actin as internal control. One-way ANOVA and linear regression analysis were used for statistical study. RESULTS:Plasma endothelin-1 increased significantly in heart failure animals. The ratio of preproET-1 to ? actin mRNA was significantly increased from 0.14?0.06 in control group to 0.35?0.08 in pacing 2 group and 0.53?0.08 in pacing 4 group ( P
