Advances in molecular mechanism in regulation of osteoclastogenesis
- VernacularTitle:破骨细胞分化成熟调节的分子机理研究进展
- Author:
Chengliang YUAN
;
Xiaolan JIN
- Publication Type:Journal Article
- Keywords:
Osteoclasts;
Osteoprotegerin;
NF-?B;
Differentiation
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Osteoprotegerin(OPG) ,receptoractivatorofNF -?Bligand (RANKL)andreceptoracti vatorofNF -??(RANK)areimportantmoleculesthatregulateosteoclastogenesis .OPGisdecoyreceptorof RANKL .ThebindingofOPGandRANKLblocksconnectingofRANKLandRANK ,inhibitsdevelopmentof osteoclast.ThebindingofRANKLandRANKinducesaserieskinasecascadereaction ,activatestranscription factors,introducestheproliferationanddifferentiationofosteoclastprecursors .Severalhormonesandos teotropicfactorsregulatetheformationandfunctionofosteoclastthroughtheabovemolecules .
