Fragile histidine triad gene deletion in breast cancer and its correlation with human papillomavirus infection
- VernacularTitle:乳腺癌中FHIT基因缺失与人乳头状瘤病毒感染相关性的研究
- Author:
Ye WANG
;
Jinping GUAN
;
Wei GAO
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Genes;
Human papillomavirus
- From:
Chinese Journal of General Surgery
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the deletion of fragile histidine triad (FHIT) gene in breast cancer and explore its relation with human papillomavirus(HPV) infection. Methods Thirty-eight breast cancer specimens and ten normal breast tissues were examined for abnormalities of FHIT gene by RT-PCR and fragment of HPV-DNA by PCR. Results The positive rates of FHIT gene deletion and HPV-DNA fragment were 63.1%(24/38) and 31.6%(12/38) respectively, while they were not detected in normal tissues (? 2=12.632,P
