The relationship between vitamin D receptor gene polymorphism and primary hyper parathyroidism
- VernacularTitle:维生素D受体基因多态性与原发性甲状旁腺功能亢进症的关系
- Author:
Qiang ZHANG
;
Xihou LIN
;
Jingming ZHAO
- Publication Type:Journal Article
- Keywords:
Hyperparathyroidism;
Receptor,calcitriol;
Polymorphism,restriction fragment length
- From:
Chinese Journal of General Surgery
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the polymorphism of the vitamin D receptor(VDR)gene in relation to primary hyperparathyroidism(PHPT). Method Polymerase chain reaction and restriction analysis were used to determine VDR genotypes in 30 patients with PHPT and in normal subjects.ResultsThe frequency distribution of VDR genotypes in PHPT patients was 0 in BB,1(3.3%) in Bb, 29(96.7%) in bb; and in normal persons was 2(3.3%) in BB, 11(18.4%) in Bb, and 47(78.3%) in bb. There was a significant difference between PHPT patients and normal persons in distribution of BB, Bb, bb genotypes (P≤0.05).ConclusionsThere is some distribution alterations of VDR gene polymorphism in PHPT patients.
