GMP_(140) Expression in IgA Nephropathy
- VernacularTitle:GMP_(140)在成人IgA肾病中的表达
- Author:
Xi ZHANG
;
Ming LI
;
Jianxin SONG
- Publication Type:Journal Article
- Keywords:
P-selectin;
IgA nephropathy;
Platelet;
Flow cytometry method
- From:
Journal of Chinese Physician
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective In order to study the relationship between the platelet activation sign:P-selectin(GMP 140 ) expression and human IgA nephropathy.Methods Expression of platelet membrane glucoprotein Ⅱb/Ⅲa(GP Ⅱb ,GP Ⅲa ) in blood for IgA nephropathy patients(n=46) was investigated by flow cytometry methods.Results In IgA nephropathy the up-regulated GMP 140 expression in blood was significantly higher than that in normal humans.Conclusions GMP 140 might play an important role in pathogenesis of IgA nephropahty,and the level of GMP 140 in blood might predict renal outcome in IgA nephropathy.
