Significance of Heparin Binding Epidermal Growth Factor-like Growth Factor in Early Psoriatic Lesions
- VernacularTitle:肝素结合表皮生长因子样生长因子在银屑病早期皮损中的意义
- Author:
Yan ZHENG
;
Zhenhui PENG
;
Shengshun TAN
;
Yanping XI
;
Yili WANG
;
Baochang LAI
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Epidermal growth factor-urogastrone;
Epidermis
- From:
Chinese Journal of Dermatology
1995;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of heparin binding epidermal growth factor-like growth factor(HB-EGF)in active psoriasis vulgaris.Methods HB-EGF mRNA and protein were detected by hy-bridization in situ and immunohistochemistry in normal skin tissues,lesional and non-lesional psoriatic skin of progressive stage.Results In normal skin tissues,the stain of HB-EGF mRNA and protein was located in the basal layer of epidermis(100.00%)and there was only a little expression in the suprabasal layers(16.67%).Focal overexpression was found in the suprabasal layers of non-lesional and peri-lesional psoriat-ic skin(88.00%,80.00%respectively);however,there was no HB-EGF mRNA protein expression in the superabasal layers of the central part of psoriatic lesions(0),and nearly no expression in the basal layer(4.00%).Conclusion HB-EGF may play an important role in the pathogenesis of early psoriasis.
