Effect of Antipsoriatic Drugs(Tripdiolide etc.)on Leukotriene A4Hydrolase Activity
- VernacularTitle:苯丁抑素和雷公藤内酯醇等对白三烯A4水解酶活性的影响
- Author:
Lianwen SUN
;
Jiarun ZHENG
;
Lanfang XU
;
Xinyu LI
- Publication Type:Journal Article
- Keywords:
Leukotriene B4;
Leukotriene A4;
Tripdiolide
- From:
Chinese Journal of Dermatology
1995;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of some compounds,bestatin,tripdiolide,etc,on leukotriene A4hydrolase activity.Methods LTB4,product of leukotriene A4hydrolase,was determined by reverse phase high performance liquid chromatography(PR-HPLC).Bestatin,an inhibitor of LTA4hydrolase was used as a positive control.Results Tripdiolide could inhibit LTA4hydrolase activity in a dose-depen-dent pattern.The50%inhibitory concentration values(IC 50 )was2.58?10 -5 ?g/mL.The other compounds,an-thralin,cyclosporin A,tretinoin,calcipotriene,clobetasol propionate,methotrexate,and erythromycin,had no effects.Conclusions Tripdiolide possibly has anti-inflammatory effect through down-regulation of leukotriene A4hydrolase in psoriasis.
