Detection of CD35on Erythrocytes and Erythrocyte Chemokine Recepter(ECKR)in Patients with Psoriasis
- VernacularTitle:银屑病患者红细胞CD35和红细胞趋化因子受体的测定
- Author:
Jun GU
;
Hui LIU
;
Feng GUO
;
Lezhi ZHANG
;
Meixian HUA
;
Chunyan XUE
;
Li LIU
;
Ping TANG
;
Baohua QIAN
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Immunity,natural;
Erythrocytes;
Receptors,complement36;
Receptors,chemokine;
Interleukin-8
- From:
Chinese Journal of Dermatology
1995;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study CD35on erythrocytes and erythrocyte chemokine recepter(ECKR)in patients with psoriasis in order to explore red blood cell(RBC)innate immune function and its possible role in the pathogenesis of psoriasis.Methods The rapid natural immune reaction on cancer cells was measured with RBCs isolated from fresh blood.Expression of CD35on erythrocytes was detected by flow cy-tometry.The level of IL-8,which was bound to isolated erythrocytes,was measured by enzyme linked im-munosorbent assay(ELISA)in the supernatant after centrifugation,which represented ECKR binding activity.Results Rosette formation rates of RBC adhering to cancer cells and expression of CD35on RBCs were significantly higher in psoriatic patients than those in control group(P
