The relationship between expression of ?_3 integrin, focal adhesion kinase and migration of vascular smooth muscle cells stimulated by extracellular matrix
- VernacularTitle:细胞外基质促血管平滑肌细胞迁移及?_3整合素和粘着斑激酶表达
- Author:
Zhimin LIU
;
Mei HAN
;
Jinkun WEN
- Publication Type:Journal Article
- Keywords:
Extracellular matrix proteins;
Muscle, smooth, vascular;
Integrins;
Focal adhesions
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the relationship between expression of ? 3 integrin, focal adhesion kinase (FAK) and migration of vascular smooth muscle cells (VSMC) stimulated by osteopontin (OPN) and fibronectin (FN).METHODS: VSMC migration was examined using a model of wounding injury of confluent cultured cells. The expression of ? 3 integrin, FAK and Gax genes in VSMC were detected using Western blotting and RT-PCR. RESULTS: OPN and FN induced the migration activity of VSMC in a time-dependent manner ( P
