The association of paraoxonase 2 gene 311Cys/Ser polymorphism and type 2 diabetes mellitus complicated by coronary heart disease
- VernacularTitle:Ⅱ型对氧磷酯酶基因311Cys/Ser多态性与2型糖尿病合并冠心病关系的研究
- Author:
Yun WANG
;
Zhiwen CHANG
- Publication Type:Journal Article
- Keywords:
Paraoxonase;
Polymorphism (genetics);
Coronary disease;
Gene;
Diabetes mellitus, non-insulin-dependent
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the association of the human paraoxonase 2 (PON2) 311Cys/Ser polymorphism genotypes and coronary heart disease (CHD) in type 2 diabetes mellitus (type 2 DM) in Chinese subjects of north area. METHODS: PON2-311 cysteine (C type) / serine (S type) polymorphism was determined using PCR and restriction mapping with DdeⅠ, in 75 elder patients with type 2 DM, 39 with CHD,36 without CHD, and 38 normal elder controls. RESULTS: There was significant difference in frequencies of genotypes between CHD in type 2 DM group and normal control group( P
