(TTTTA)n polymorphism analysis in the 5' control region of apollipoprotein(a) gene in patients with coronary heart disease and the association with serum lipid level
- VernacularTitle:载脂蛋白(a)5’调控区(TTTTA)n基因多态性与冠心病及其血清脂质的关系
- Author:
Bo HU
;
Xin ZHOU
;
Minjian LIANG
;
Zhaoxia LI
;
Jiayi LIANG
- Publication Type:Journal Article
- Keywords:
Apolipoproteins A;
Lipoprotein a;
Gene polymorphism;
Coronary disease
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the pentanucleotide repeat(PNR) polymorphism of apolipoprotein(a) in patients with coronary heart disease(CHD) in Hubei area, and evaluate the association of polymorphism of apo(a) PNR with the level of serum lipid. METHODS: Objects examined were composed of two groups: 88 patients with CHD and 153 healthy controls. Lp(a), TC,TG, HDL-C, LDL-C, ApoAⅠand ApoB of two groups were tested. Meanwhile,the PNR in the 5' control region of the Apo(a) was detected by using polymerase chain reaction (PCR) and high voltage polyacrylamid gels electropherosis. RESULTS: The serum Lp(a), TC, TG and LDL-C levels were remarkably higher in the CHD than that in control( P
