Inhibitory effect of interferon ?-2b on atherosclerosis
- VernacularTitle:?-2b干扰素抑制动脉粥样硬化的实验研究
- Author:
Le GUI
;
Maoyin CAO
;
Jianghua REN
;
Zhanqi YANG
- Publication Type:Journal Article
- Keywords:
Atherosclerosis;
Herpesvirus Ⅰ;
Platelet-derived growth factor;
Interferon alfa-2B
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To evaluate the effects of interfer ?-2b (IFN ?-2b ) on atherosclerosis(AS).METHODS: Thirty normal male rabbits were randomly divided into five groups:normal control group(NC group, n= 6), atherosclerosis group(AS group, n =6),virus (herpesvirus Ⅰ,HSV-Ⅰ)infected atherosclerosis group(V group, n= 6), interferon (interferon ?-2b) intervented atherosclerosis group (IFN-Ⅰgroup, n= 6),interferon intervented and virus infected atherosclerosis group (IFN-Ⅱ group, n= 6). Serum lipids were measured and the thoracic aortas were sampled for histopathological, immunohistochemical and in situ hybridization study. RESULTS: The aorta atherosclerosis areas of NC, IFN-Ⅰ and IFN-Ⅱ groups were lower than that of AS group significantly, respectively, and the area of AS group was lower than that of V group ( P
