Effect of repeated measles vaccine injection on interleukin-12, interleukin-13 levels in asthmatic children
- VernacularTitle:麻疹疫苗反复注射对哮喘患儿IL-12、IL-13水平的影响
- Author:
Weiping TAN
;
Shaoliang HUANG
;
Xiandi MAI
;
Li ZHAO
;
Baoqing WU
;
Huarong HUANG
;
Changguo ZHU
;
Yanfeng WU
- Publication Type:Journal Article
- Keywords:
Asthma;
Measles vaccine;
Interleukin-12;
Interleukin-13
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM and METHODS: To study the immunological effect of measles vaccine therapy on asthmatic children, we examined the changes of interleukin-12 , interleukin-13 and total serum IgE levels in plasma and cultured peripheral blood mononuclear cells(PBMC) supernatant by means of ELISA in 13 mild-moderate asthmatic children treated with measles vaccine. Results were compared with 12 anti-symptomatic treatment mild-moderate asthmatic children and 17 normal children control group. RESULTS:After measles vaccine treatment, IL-13 and total serum IgE levels decreased remarkably, statistically lower than that of group receiving only anti-symptomatic treatment. There was no statistical difference in IL-12 level between the two group. Correlation analysis: 1)IL-12 level of plasma was negatively correlated to the level of serum total IgE, there was no correlation of supernatant IL-12 in PBMC to the total serum IgE; 2)IL-13 levels in plasma and PBMC were positively correlated to the level of total serum IgE; 3) IL-12 level was negatively correlated to IL-13. CONCLUSION: Measles vaccine could down-regulate IL-13 level, therefore decrease total IgE synthesis, but not affect IL-12 level in asthmatic children.
