Role of endogenous arginine vasopressin in   soman-induced               hypothermia in rats

VernacularTitle:内源性精氨酸加压素在索曼引起的大鼠体温降低中的作用(英文)
Author: Yonglu YANG ; Lihua LIU ; Yin ZHANG
Publication Type:Journal Article
Keywords: Soman; Arginine vasopressin; Hypothermia; Rats
From: Chinese Journal of Pathophysiology 1986;0(02):-
CountryChina
Language:Chinese
Abstract: AIM: This study was designed to examine whether endogenous arginine vasopressin (AVP) is involved in soman-induced hypothermic process. METHODS: Core temperature was measured at 60 min intervals with digital thermometer. Effect of AVP V 1 receptor antagonist (30 ?g/kg, ip) on soman-induced hypothermia was observed in rats, and plasma AVP concentration was measured at 2 h after administration of soman(60 ?g/kg, sc). RESULTS: Administration of soman led to a marked hypothermia. Core temperature recovered to basal levels at 7 h after soman treatment. Plasma AVP concentration increased markedly at 2 h after soman treatment, and administration of AVP V 1 receptor antagonist markedly blocked the hypothermic effect of soman. CONCLUSION: The data indicate that AVP is involved in soman-induced hypothermia in the rat.