Role of bradykinin in the therapeutic effect of enalapril on left ventricular hypertrophy and cardiac function after myocardial infarction in rats
- VernacularTitle:缓激肽在依那普利对心肌梗死大鼠心肌肥厚及心功能影响中的作用
- Author:
Haizhu ZHANG
;
Liquan LEI
;
Changcon CUI
- Publication Type:Journal Article
- Keywords:
Bradykinin;
Myocardial hypertrophy;
Myocardial infraction;
Angiotensin-converting enzyme inhihitors;
Rats
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the influences of bradykinin(BK)on left ventricular hypertrophy and cardiac function in angiotensin-converting enzyme inhibitor(ACEI) therapy in rats after myocardial infarction. METHODS: The effects of enalapril (500 ?g?kg -1 ?d -1 ), enalapril (500 ?g?kg -1 ?d -1 )with BKB 2 receptor antagonist (Hoe-140 500 ?g?kg -1 ?d -1 ), losartan(3 mg?kg -1 ?d -1 ) on left ventricular end-diastolic pressure (LVEDP), maximum positive left ventricular pressure change (+d p /d t max ) and LVW/BW as well as V(m)n of noinfarcted area were examined after 4 weeks treatment in rats after myocardial infarction. RESULTS: The values of LVEDP, LVW/BW and V(m)n of three treatment groups were higher than that of untreated MI group ( P
