Detection of the aberration of X chromosome in hepatocellular carcinoma cell lin e HCC-9903 by fluorescence in situ hybridization（FISH）
- VernacularTitle:应用FISH技术对肝癌细胞系HCC-9903X染色体变异的研究
- Author:
Jun LIU
;
Zhanmin WANG
;
Shufang ZHENG
- Publication Type:Journal Article
- Keywords:
Carcinoma, hepatocellular;
X chromosome;
In situ hybridization,fluorescence
- From:
Chinese Journal of General Surgery
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the X chromosome aberration in hepatocellular carcinoma cell line HCC-9903. Method The hepatocellular carc inoma cell line, HCC-9903, was detected by fluorescence in situ hybridization ( FISH) centromere DNA probes of X chromosome. Result Increased X chromosome copy number was observed in HC C-9903 cell line , four signals of hybridization was the major type. Conclusion Gain of X chromosome freq uently occurred in liver carcinoma. The relationship between gain of X chromosom e and liver carcinoma genesis needs further investigation.
