Effects of angiotensin Ⅱ receptor antagonist on VEGF expression in cirrhotic rats
- VernacularTitle:血管紧张素Ⅱ受体拮抗剂对大鼠肝硬化时VEGF基因表达的影响
- Author:
Lixin LI
;
Yu WANG
;
Zhongtao ZHANG
- Publication Type:Journal Article
- Keywords:
Cirrhosis;
VEGF;
AngiotensinⅡ;
Receptor;
Antagonist
- From:
Chinese Journal of General Surgery
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of L osartan, an angiotensin Ⅱ type receptor antagonist, on vascular endothelial gro wt h factor (VEGF) expression. Method Ｚ Liver cirrhosis was in duced by oral intake of 50% CCl4 at a dosage of 3?ml?kg-1?d- 1ⅹ 9 weeks in SD rats. In Losartan group,rats were given Losartan orally. Exp r ession of VEGFmRNA was examined with reverse transcriptase polymerase chain reac tion (RT-PCR) and the expression of VEprotein was assayed by immunohistochem istry. Result VEGF was highly e xpressed in cirrhotic group compared with control group (0.77?0.10 vs 1.94? 0.20, P=0.001) . In losartan treatment group, VEGF mRNA expression decreas ed to 1.02?0.1 and 0.86?0.15（P=0.001）. Concl usion Expression of VEGF increased in cirrhosis, Losartan inhibited this eff ect.
