Association of apoptosis of tumor cells with P53 gene in rat implanted Warlker-256 treated by magnetic field
- VernacularTitle:恒强磁场下的大鼠肿瘤细胞凋亡和P53基因的关系
- Author:
Hua LIU
;
Jiacheng REN
;
Youmin GUO
- Publication Type:Journal Article
- Keywords:
Forensic pathology;
Permanent magnetic field;
Warlker-256;
P53;
Apoptosis
- From:
Chinese Journal of Forensic Medicine
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To probe the mechanism of Warlker-256 cell apoptosis resulted from permanent and strong magnetic field. Method The amplification, rearrangement, deletion, transcription and expression of P53 were detected in 320 rats treated by magnetic field and 80 controls, using Dot Blot of DNA and RNA, Southern and Northern blot, and immunohistochemical technologies. Results P53 is wild type in Warlker-256 cells, no amplification, rearrangement and deletion were found in either magnetic treated group or control group. The transcription and expression of P53 is significantly enhanced in the treated group versus the control(P
