Study on GFAP changes of astrocyte and expression of endothelin-1 in brainstem injury of human being
- VernacularTitle:脑干损伤致死星形胶质细胞GFAP和ET-1的表达
- Author:
Jian LI
;
Hua LIU
;
Li LIU
- Publication Type:Journal Article
- Keywords:
Forensic pathology;
Brainstem injury;
Glial Fibrillory Acidic Protein (GFAP), En-dothelin-1 (ET-1)
- From:
Chinese Journal of Forensic Medicine
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study GFAP changes of astrocyte and expression of Endothelin-1 in molecular pathology in brainstem injury of human being and explore its forensic medical significance. Method 15 brain specimens of acute brainstem injury and 5 brain specimens of no brainstem injury in different time were selected and their microscopic morphological changes were observed with HE staining, and we study the pathological changes of GFAP of astrocyte and expression of Endothelin-1 in monoclonal antibody im-munohistochemistry SP method. Results The number of GFAP positive cells was increased, the bulk of the cell became bigger and expression of Endothelin-1 could be observed. Conclusion The above pathological changes might be a valuable base used for postmortem diagnosis of acute brainstem injury.
